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| Cata #: | Name of Product: | Price: |
| HRP-4394 | Recombinant Human FAM171A2 Protein | $300 |
| Product Name: | Recombinant Human FAM171A2 Protein |
| Catalog #: | HRP-4394 |
| Manufacture: | LD Biopharma, Inc. |
| Introduction: | Human FAM171A2 gene encodes a cell membrane protein which is associated with frontotemporal dementia and Grn-Related Frontotemporal Lobar Degeneration. It is also a key regulator of progranulin (PGRN) expression, which affects the risk of various neurodegenerative diseases. Additionally, FAM171A2 is a potential receptor for the neuronal uptake of α-synuclein fibrils, potentially mediating their internalization through endocytosis and drives Parkinson’s disease. Full-length extracellular domain of human FAM171A2 cDNA (30–315aa) was constructed with codon optimization gene synthesis and expressed with a human Alpha Fetal Protein N-terminal (AFPn) -His-TEV cleavage site Tag (217aa) fusion at its N-terminal in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified. |
| Gene Symbol: | FAM171A2 |
| Accession Number: | NP_940877 |
| Species: | Human |
| Package Size: | 40 µg / Vial |
| Composition: | 0.4 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT and others. |
| Storage: | In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days. |
| Key Reference: | Kai-Min Wu, et al., Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson’s disease. Science.20 Feb 2025 Vol 387, Issue 6736. pp. 892-900. DOI: 10.1126/science.adp364 |
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| Quality Control: | Purity: > 92% by SDS-PAGE. |
| Recombinant Protein Sequence: | MTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSGGSHHHHHHGSENLYFQGGEKSPPEPPSPQEILIKVQVYVSGELVPLARASVDVFGNRTLLAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLPLYASVSLYLLPERPATLILYEDLVHILLGSPGARSQPLVQFQRRAARLPVSSTYSQLWASLTPASTQQEMRAFPAFLGTEASSSGNGSWLELMPLTAVSVHLLTGNGTEVPLSGPIHLSLPVPSETRALTVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWTFVSPQLGYWVAAMASPTAGLVTITSGIQDIGTYHT |