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| Cata #: | Name of Product: | Price: |
| HRP-2735 | Recombinant Human IGF2 Protein | $200 |
| Product Name: | Recombinant Human IGF2 Protein |
| Catalog #: | HRP-2735 |
| Manufacture: | LD Biopharma, Inc. |
| Intruduction: | Human Insulin-like growth factor –II (IGF2) gene encodes an insulin-like growth factors, which possess growth-promoting activity. As major fetal growth hormone in mammals, it plays a key role in regulating fetal placental development. IGF-II is influenced by placental lactogen. It is also involved in tissue differentiation. It positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional co-activators, thereby controlling muscle terminal differentiation. In adults, IGF2 is involved in glucose metabolism in adipose tissue, skeletal muscle and liver. It acts as a ligand for integrin which is required for IGF2 signaling. Full-length mature form of human IGF2 cDNA ( 25 – 91aa ) was constructed with codon optimization gene synthesis and expressed with a human alpha Fetal Protein N-terminal (AFPn) -His-TEV cleavage site Tag (217aa) fusion at its N-terminal in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified. |
| Gene Symbol: | IGF2 ( GRDF; PP9974; C11orf43 ) |
| Accession Number: | NP_000603 |
| Species: | Human |
| Package Size: | 30 µg / Vial |
| Composition: | 0.3 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT and others. |
| Storage: | In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days. |
| Key Reference: | Brown TC, et al.,Insulin-Like Growth Factor and SLC12A7 dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinoma. J Am Coll Surg. Apr 26.pii:s1072-7515. (2019)
Ziegier AN, et al.,Insulin-Like Growth Factor II: An Essential Adult Stem cell Niche Constituent in Brain and Intestine. Stem Cell Reports. Apr 9;12(4): 816-830 (2019)
Daimon M, et al.,The third IGF-II promoter specifies transcription of three transcripts out of five in human placenta. Mol. Reprod. Dev. 33 (4), 413-417 (1992)
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| Quality Control: | Purity: > 92 % by SDS-PAGE. |
| Recombinant Protein Sequence: | MTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSGGSHHHHHHGSENLYFQGAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSE Download Datasheet |