|Product Name:||Recombinant Human FAM49A -11R Protein|
|Manufacture:||LD Biopharma, Inc.|
Human FAM49 family have at least two members, FAM49A and FAM49B. We know very little about FAM49A gene function, except it is highly enriched in neocortex. Recent data indicated that CYRI, which is Fam49 related protein in Dictyosteium, is a regulator of the dynamics of the Rac1–Scar/WAVE pathway, providing plasticity and adding complexity to leading-edge dynamics. FAM49B has been demonstrated to paly important role in controlling actin dynamics in T cell activation pathway.
|Package Size:||20 µg / Vial|
|Composition:||0.2 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT and Others.|
|Storage:||In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.|
Fort L, et al., Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nat Cell Biol. Oct: 20(10): 1159-1171. (2018)
Chen C, et al., Genetic variants of MGMT, RHPN2, and FAM49A contributed to susceptibility of nonsyndromic orofacial clefts in a Chinese population. J. Oral Pathol. Med. 47 (8), 796-801 (2018)
1. May be used for in vitro FAM49A mediated signaling pathway regulation study for neuronal cells differentiation by directly intracellular delivery of this 11R tag FAM49A protein .
|Quality Control:||Purity: > 90% by SDS-PAGE.|
|Recombinant Protein Sequence:||