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| Cata #: | Name of Product: | Price: |
| HRP-2393 | Recombinant Human CD235a Protein | $150 |
| Product Name: | Recombinant Human CD235a Protein |
| Catalog #: | HRP-2393 |
| Manufacture: | LD Biopharma, Inc. |
| Intruduction: | Human Glycophorin A gene ( also named as CD235a) encodes a major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 ( CD233 ) and is required for high activity of SLC4A1. CD235a may be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. It is also a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). Full-length extracellular domain of human CD235a cDNA (20 – 91aa, derived from BC005319) was constructed with codon optimization gene synthesis and expressed with a human alpha Fetal Protein N-terminal (AFPn) -His-TEV cleavage site Tag (217aa) fusion at its N-terminal in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified. |
| Gene Symbol: | CD235a |
| Accession Number: | NP_002090.4 |
| Species: | Human |
| Package Size: | 50ug / vial |
| Composition: | 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT and others. |
| Storage: | In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days. |
| Key Reference: | Sturgeon CM, et al. Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells. Nat Biotechnol. 32:554–61. (2014) Sisquella X, et al., Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion. Elife 6, e21083 (2017) Giger K, et al., Diffusion of glycophorin A in human erythrocytes Biochim. Biophys. Acta 1858 (11), 2839-2845 (2016) |
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| Quality Control: | Purity: > 93% by SDS-PAGE. |
| Recombinant Protein Sequence: | MTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSGGSHHHHHHGSENLYFQGLSTTEVAMHTSTSSSVTKSYISSQTNDTHKRDTYAATPRAHEVSEISVRTVYPPEEETGERVQLAHHFSEPE Download Datasheet |