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| Cata #: | Name of Product: | Price: |
| HRP-1981 | Recombinant Human FABP4 Protein | $300 |
| Product Name: | Recombinant Human FABP4 Protein |
| Catalog #: | HRP-1981 |
| Manufacture: | LD Biopharma, Inc. |
| Intruduction: | The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR. Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity. FABP4 protein is dominantly expressed in adipocytes, as lipid transport protein. It binds both long chain fatty acids and retinoic acid. FABP4 delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Full-length of human FABP4 cDNA (131aa ) was constructed with codon optimization and expressed with a small T7-His-TEV cleavage site Tag (31aa) fusion at its N-terminal. It was expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified. |
| Gene Symbol: | FABP4 (A-FABP; ALBP; aP2; HEL-S-104) |
| Accession Number: | NP_001433.1 |
| Species: | Human |
| Package Size: | 50 µg / Vial |
| Composition: | 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT. |
| Storage: | In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days. |
| Key Reference: | Alqahtani MF, et al., Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid-Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein. PLoS ONE 11 (4), E0153645 (2016) Zhang S, et al., Circulating Adipocyte Fatty Acid Binding Protein (FABP4) Levels Are Associated with Irisin in the Middle-Aged General Chinese Population. PLoS ONE 11 (1), E0146605 (2016) Saavedra P, et al., New insights into circulating FABP4: Interaction with cytokeratin 1 on endothelial cell membranes. Biochim. Biophys. Acta 1853 (11 PT A), 2966-2974 (2015) Reiser H, et al., Circulating FABP4 is a prognostic biomarker in patients with acute coronary syndrome but not in asymptomatic individuals. Arterioscler. Thromb. Vasc. Biol. 35 (8), 1872-1879 (2015) |
| Applications: | 1. May be used for in vitro FABP4 mediated long-chain fatty acid metabolism regulation study for adipocytes by intracellular delivery of this protein with protein delivery reagent such as ProFectin reagent kit. 2. May be used for mapping protein-protein interaction. 3. May be used as enzymatic substrate for various proteases. 4. Potential biomarker protein for cardiovascular diseases diagnostic applications. 5. As immunogen for specific antibody production. |
| Quality Control: | Purity: > 90% by SDS-PAGE. |
| Recombinant Protein Sequence: | MASMTGGQQMGRGHHHHHHGNLYFQGGEFCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA Download Datasheet |